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Efficacies of calcium-EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coli with NDM-1 ß-lactamase.
Yoshizumi, Ayumi; Ishii, Yoshikazu; Livermore, David M; Woodford, Neil; Kimura, Soichiro; Saga, Tomoo; Harada, Sohei; Yamaguchi, Keizo; Tateda, Kazuhiro.
Afiliação
  • Yoshizumi A; Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine, Tokyo, 143-8540, Japan.
J Infect Chemother ; 19(5): 992-5, 2013 Oct.
Article em En | MEDLINE | ID: mdl-23233082
We evaluated the efficacy of ethylenediamine-N,N,N',N'-tetraacetic acid, disodium calcium salt (Ca-EDTA), as an inhibitor for New Delhi metallo-ß-lactamase-1 (NDM-1) in vitro antibiotic susceptibility and in a mouse model of sepsis caused by Escherichia coli. Ca-EDTA drastically reduced the MICs of carbapenems for all NDM-producing bacteria [imipenem (IPM) ≤1-2 µg/ml; meropenem (MEPM) ≤1-4 µg/ml]. In the neutropenic murine model of sepsis, the bacterial burden was further reduced by combination therapy using imipenem/cilastatin sodium (IPM/CS) and Ca-EDTA to 2.3 × 10(3) CFU/liver, compared with 2.9 × 10(4) CFU/liver for IPM/CS alone. These data demonstrated the possibility of Ca-EDTA for clinical applications. In our understanding, this is the first report examining the effect of Ca-EDTA on a mouse sepsis model caused by NDM-1-producing bacteria.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Beta-Lactamases / Imipenem / Ácido Edético / Sepse / Escherichia coli / Infecções por Escherichia coli / Antibacterianos Idioma: En Revista: J Infect Chemother Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Beta-Lactamases / Imipenem / Ácido Edético / Sepse / Escherichia coli / Infecções por Escherichia coli / Antibacterianos Idioma: En Revista: J Infect Chemother Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Japão