Fluevirosines A-C: a biogenesis inspired example in the discovery of new bioactive scaffolds from Flueggea virosa.

Zhang, Hua; Zhang, Chuan-Rui; Zhu, Kong-Kai; Gao, An-Hui; Luo, Cheng; Li, Jia; Yue, Jian-Min

Zhang, Hua; Zhang, Chuan-Rui; Zhu, Kong-Kai; Gao, An-Hui; Luo, Cheng; Li, Jia; Yue, Jian-Min.

Afiliação

Zhang H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

Org Lett ; 15(1): 120-3, 2013 Jan 04.

Article em En | MEDLINE | ID: mdl-23244193

ABSTRACT

ABSTRACT

Biogenesis inspired chemical investigation of a Chinese folk medicine, Flueggea virosa, returned three unprecedented C,C-linked trimeric Securinega alkaloids, fluevirosines A-C (1-3). Their absolute structures were characterized on the basis of spectroscopic data and computational analysis. Compounds 2 and 3 showed inhibition against the splicing of XBP1 mRNA.

Assuntos

Alcaloides/farmacologia; Euphorbiaceae/química; RNA Mensageiro/efeitos dos fármacos; Alcaloides/química; Alcaloides/isolamento & purificação; Estrutura Molecular; Ressonância Magnética Nuclear Biomolecular

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Euphorbiaceae / Alcaloides Idioma: En Revista: Org Lett Ano de publicação: 2013 Tipo de documento: Article

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google