Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells.
Arch Pharm Res
; 36(6): 768-74, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23456692
ABSTRACT
Twenty-four oleanane-type triterpenoid saponins were isolated from a methanol extract of the Pulsatilla koreana roots. Their structures were elucidated by comparing spectroscopic data to published values. Among them, compounds 8-12 and 20-24 significantly diminished the proliferation of HL-60 human promyelocytic leukemia cells with IC50 values from 0.3 to 4.2 µM, whereas compounds 7 and 19 showed moderate cytotoxic activity. Furthermore, apoptotic characteristics such as chromatin condensation and increase in the population of sub-G1 hypodiploid cells were observed after the HL-60 cells were treated with these compounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Saponinas
/
Leucemia Promielocítica Aguda
/
Pulsatilla
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2013
Tipo de documento:
Article