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Effects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats.
Oguz, Serhat; Kanter, Mehmet; Erboga, Mustafa; Toydemir, Toygar; Sayhan, Mustafa Burak; Onur, Hatice.
Afiliação
  • Oguz S; Department of General Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey.
  • Kanter M; Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey mkanter65@yahoo.com.
  • Erboga M; Department of Histology and Embryology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
  • Toydemir T; Department of General Surgery, Istanbul Surgical Hospital, Istanbul, Turkey.
  • Sayhan MB; Department of Emergency Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
  • Onur H; Department of Pediatrics, Istanbul Research and Training Hospital, Istanbul, Turkey.
Toxicol Ind Health ; 31(5): 475-84, 2015 May.
Article em En | MEDLINE | ID: mdl-23456814
The present study was performed to investigate the effect of Urtica dioica (UD) on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated, PH and PH + UD; each group contains eight animals. The rats in UD-treated groups were given UD oils (2 ml/kg/day) once a day orally for 7 days starting 3 days prior to hepatectomy operation. At day 7 after resection, liver samples were collected. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated deoxyuridine triphosphate nick end-labeling assay, apoptotic index (AI) were evaluated at day 7 after hepatectomy. As a result, UD significantly increased MI and PI, significantly decreased AI and also attenuated hepatic vacuolar degeneration and sinusoidal congestion in PH rats. UD treatment significantly decreased the elevated tissue MDA level and increased the reduced SOD activity and GSH level in the tissues. These results suggest that UD pretreatment was beneficial for rat liver regeneration after partial hepatectomy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Estresse Oxidativo / Urtica dioica / Preparações de Plantas / Proliferação de Células / Regeneração Hepática Idioma: En Revista: Toxicol Ind Health Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Estresse Oxidativo / Urtica dioica / Preparações de Plantas / Proliferação de Células / Regeneração Hepática Idioma: En Revista: Toxicol Ind Health Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia