Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors.
Clin Chem
; 36(6): 846-8, 1990 Jun.
Article
em En
| MEDLINE
| ID: mdl-2357820
ABSTRACT
Iron-depleted donors are at increased risk of developing anemia; if these donors could be identified by a screening test, iron supplementation or decreased donation frequency could be considered. Tests to determine serum ferritin, blood hemoglobin, and erythrocyte (Erc)-zinc protoporphyrin concentrations were examined in 679 consecutive female blood donors to identify donors with non-anemic iron deficiency. The test to determine serum ferritin is expensive and slow, whereas the two latter tests are rapid and less costly and could therefore be used for screening. Women in the fertile age groups had the lowest average serum ferritin values. In all, 93 women (13.7%) had depleted iron stores, as indicated by serum ferritin concentrations less than 14 micrograms/L. In these women, a much better correlation was found between Erc-zinc protoporphyrin and serum ferritin (rs = -0.49, P less than 0.001) than between blood hemoglobin and serum ferritin (rs = 0.31, P less than 0.01). These findings suggest that measurement of Erc-zinc protoporphyrin is superior to that of blood hemoglobin in identifying donors with non-anemic iron deficiency.
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Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Protoporfirinas
/
Doadores de Sangue
/
Eritrócitos
/
Deficiências de Ferro
/
Anemia Hipocrômica
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
Clin Chem
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Dinamarca