Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on ß-cell function and insulin sensitivity.
Reproduction
; 145(6): 609-20, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23613616
ABSTRACT
Dietary protein restriction during pregnancy and lactation in rats impairs ß-cell function and mass in neonates and leads to glucose intolerance in adult offspring. Maternal taurine (Tau) supplementation during pregnancy in rats restores ß-cell function and mass in neonates, but its long-term effects are unclear. The prevention of postnatal catch-up growth has been suggested to improve glucose tolerance in adult offspring of low-protein (LP)-fed mothers. The objective of this study was to examine the relative contribution of ß-cell dysfunction and insulin resistance to impaired glucose tolerance in 130-day-old rat offspring of LP-fed mothers and the effects of maternal Tau supplementation on ß-cell function and insulin resistance in these offspring. Pregnant rats were fed i) control, ii) LP, and iii) LP+Tau diets during gestation and lactation. Offspring were given a control diet following weaning. A fourth group consisting of offspring of LP-fed mothers, maintained on a LP diet following weaning, was also studied (LP-all life). Insulin sensitivity in the offspring of LP-fed mothers was reduced in females but not in males. In both genders, LP exposure decreased ß-cell function. Tau supplementation improved insulin sensitivity in females and ß-cell function in males. The LP-all life diet improved ß-cell function in males. We conclude that i) maternal Tau supplementation has persistent effects on improving glucose metabolism (ß-cell function and insulin sensitivity) in adult rat offspring of LP-fed mothers and ii) increasing the amount of protein in the diet of offspring adapted to a LP diet after weaning may impair glucose metabolism (ß-cell function) in a gender-specific manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Resistência à Insulina
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Dieta com Restrição de Proteínas
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Suplementos Nutricionais
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Fenômenos Fisiológicos da Nutrição Materna
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Diabetes Mellitus Tipo 2
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Células Secretoras de Insulina
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Idioma:
En
Revista:
Reproduction
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Canadá