[Effect of Huangqi gegen decoction (HGD) on TGF-beta1/Smad3 pathway in diabetic cardiomyopathy rats].
Zhong Yao Cai
; 35(11): 1809-13, 2012 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-23627095
ABSTRACT
OBJECTIVE:
To study the effect of HGD on diabetic cardiomyopathy and its mechanism.METHODS:
The T2-DM rats model was established by combining high fat diet with STZ. The blood glucose, insulin, myocardial fibrosis and TGF-beta1/Smad3 signaling pathway were observed; TGF-beta1 and Smad3 mRNA expression were detected by RT-PCR method, protein expression detected by immunohistochemical method.RESULTS:
HGD obviously reduced fasting blood glucose, insulin, improved insulin resistance, reduced myocardial hydroxyproline contents, lowered cardiac index, significantly inhibited over-expression of TGF-beta1/SMAD3 mRNA and protein in diabetic rats cardiac.CONCLUSION:
HGD can obviously prevent experimental diabetic myocardial fibrosis through the regulation effect on TGFbeta1/Smad3 signaling pathway.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Medicamentos de Ervas Chinesas
/
Diabetes Mellitus Experimental
/
Proteína Smad3
/
Fator de Crescimento Transformador beta1
/
Cardiomiopatias Diabéticas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
Zhong Yao Cai
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China