Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa.
Fitoterapia
; 89: 1-7, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23651559
ABSTRACT
Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values 4-128 µg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values 15.85-56.36 µM).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Quinolonas
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Evodia
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Alcaloides
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Fitoterapia
/
Antibacterianos
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Neoplasias
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Antineoplásicos Fitogênicos
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2013
Tipo de documento:
Article