Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.
Nat Commun
; 4: 1867, 2013.
Article
em En
| MEDLINE
| ID: mdl-23695661
ABSTRACT
Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Here we show that nanoparticles made of grapefruit-derived lipids, which we call grapefruit-derived nanovectors, can deliver chemotherapeutic agents, short interfering RNA, DNA expression vectors and proteins to different types of cells. We demonstrate the in vivo targeting specificity of grapefruit-derived nanovectors by co-delivering therapeutic agents with folic acid, which in turn leads to significantly increasing targeting efficiency to cells expressing folate receptors. The therapeutic potential of grapefruit-derived nanovectors was further demonstrated by enhancing the chemotherapeutic inhibition of tumour growth in two tumour animal models. Grapefruit-derived nanovectors are less toxic than nanoparticles made of synthetic lipids and, when injected intravenously into pregnant mice, do not pass the placental barrier, suggesting that they may be a useful tool for drug delivery.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Citrus paradisi
/
Nanopartículas
/
Lipídeos
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Antineoplásicos
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos