Pyrrolizidine alkaloids and fatty acids from the endemic plant species Rindera umbellata and the effect of lindelofine-N-oxide on tubulin polymerization.
Molecules
; 18(9): 10694-706, 2013 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-24005964
ABSTRACT
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (¹H- and ¹³C-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Pirrolizidina
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Sementes
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Tubulina (Proteína)
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Extratos Vegetais
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Boraginaceae
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Moduladores de Tubulina
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Ácidos Graxos
Idioma:
En
Revista:
Molecules
Ano de publicação:
2013
Tipo de documento:
Article