Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS.
Gynecol Endocrinol
; 30(3): 205-8, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24351072
ABSTRACT
Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous bio-physical features, affected by PCOS and menstrual irregularities, and we randomly divided them into two groups 25 were treated with 4 g of myo-inositol/die plus 400 mcg of folic acid/die orally for six months, 25 with 1 g of D-chiro-inositol/die plus 400 mcg of folic acid/die orally for six months. We analyzed in both groups pre-treatment and post-treatment BMI, systolic and diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, dehydroepiandrosterone sulfate (DHEA-S), Δ-4-androstenedione, SHBG, prolactin, glucose/immunoreactive insulin (IRI) ratio, homeostatic model assessment (HOMA) index, and the resumption of regular menstrual cycles. Both the isoforms of inositol were effective in improving ovarian function and metabolism in patients with PCOS, although myo-inositol showed the most marked effect on the metabolic profile, whereas D-chiro-inositol reduced hyperandrogenism better.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Síndrome do Ovário Policístico
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Resistência à Insulina
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Hiperandrogenismo
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Suplementos Nutricionais
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Inositol
/
Distúrbios Menstruais
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
País/Região como assunto:
Europa
Idioma:
En
Revista:
Gynecol Endocrinol
Ano de publicação:
2014
Tipo de documento:
Article