Selenium and selenocysteine: roles in cancer, health, and development.
Trends Biochem Sci
; 39(3): 112-20, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24485058
ABSTRACT
The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid-1990s selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace, elucidating its many roles in health, development, and in cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Selenocisteína
/
Selenoproteínas
/
Proteínas de Neoplasias
/
Neoplasias
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2014
Tipo de documento:
Article