Potential chemoprevention of LPS-stimulated nitric oxide and prostaglandin E2 production by &#945;-L-rhamnopyranosyl-(1â6)-ß-D-glucopyranosyl-3-indolecarbonate in BV2 microglial cells through suppression of the ROS/PI3K/Akt/NF-&#954;B pathway.

Dilshara, Matharage Gayani; Lee, Kyoung-Tae; Choi, Yung Hyun; Moon, Dong-Oh; Lee, Hak-Ju; Yun, Sung Gyu; Kim, Gi-Young

Potential chemoprevention of LPS-stimulated nitric oxide and prostaglandin E2 production by α-L-rhamnopyranosyl-(1â6)-ß-D-glucopyranosyl-3-indolecarbonate in BV2 microglial cells through suppression of the ROS/PI3K/Akt/NF-κB pathway.

Dilshara, Matharage Gayani; Lee, Kyoung-Tae; Choi, Yung Hyun; Moon, Dong-Oh; Lee, Hak-Ju; Yun, Sung Gyu; Kim, Gi-Young.

Afiliação

Dilshara MG; Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Ara-1 dong, Jeju 690-756, Republic of Korea.
Lee KT; Division of Wood Chemistry & Microbiology, Department of Forest Products, Korea Forest Research Institute, 57 Hoegiro, Dongdaemun-gu, Seoul 130-712, Republic of Korea.
Choi YH; Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan 614-050, Republic of Korea.
Moon DO; Department of Biology Education, Daegu University, Jillyang, Gyeongsan, Gyeongbuk 712-714, Republic of Korea.
Lee HJ; Division of Wood Chemistry & Microbiology, Department of Forest Products, Korea Forest Research Institute, 57 Hoegiro, Dongdaemun-gu, Seoul 130-712, Republic of Korea.
Yun SG; Department of Biology Education, Daegu University, Jillyang, Gyeongsan, Gyeongbuk 712-714, Republic of Korea.
Kim GY; Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Ara-1 dong, Jeju 690-756, Republic of Korea. Electronic address: immunkim@jejunu.ac.kr.

Neurochem Int ; 67: 39-45, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24486459

Assuntos

Anticarcinógenos/farmacologia; Dinoprostona/biossíntese; Dissacarídeos/farmacologia; Indóis/farmacologia; Lipopolissacarídeos/farmacologia; Microglia/efeitos dos fármacos; Óxido Nítrico/biossíntese; Transdução de Sinais/efeitos dos fármacos; Animais; Linhagem Celular; Cromatografia por Troca Iônica; Espectroscopia de Ressonância Magnética; Camundongos; Microglia/enzimologia; Microglia/metabolismo; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Nitric oxide; Nuclear factor-κB; PI3K/Akt; Prostaglandin E(2); Reactive oxygen species; α-l-Rhamnopyranosyl-(1â6)-ß-d-glucopyranosyl-3-indolecarbonate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dinoprostona / Transdução de Sinais / Lipopolissacarídeos / Anticarcinógenos / Microglia / Dissacarídeos / Indóis / Óxido Nítrico Idioma: En Revista: Neurochem Int Ano de publicação: 2014 Tipo de documento: Article

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