Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume.
Food Chem
; 156: 408-15, 2014 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-24629988
ABSTRACT
The present study investigated the antioxidant and anti-osteoporosis activities of phytochemicals in the fruits of Prunus mume. From the methanol extract, three new acylated sucroses, mumeoses P-R (1-3), were isolated together with 20 known compounds (4-23). Compounds 1-3 showed potent peroxyl radical-scavenging activities and 12-19 showed both potent peroxyl radical-scavenging and reducing activities. The anti-osteoporosis activity was evaluated using murine pre-osteoblastic MC3T3-E1 cells and pre-osteoclastic RAW 264.7 cells. Compounds 2 and 3 (cis-trans isomers), 5, 7, 8, and 10 significantly stimulated the differentiation of pre-osteoblastic MC3T3-E1 cells to increase collagen synthesis or mineralization functions of osteoblasts, while compounds 5, 6, 9, 10, 12, 14-16, 18, 20, and 22 significantly suppressed tartrate-resistant acid phosphatase activity in receptor activator of nuclear factor-κB ligand-induced osteoclastic RAW 264.7 cells. These results indicated that the fruits of P. mume are an excellent source of antioxidant and anti-osteoporosis phytochemicals.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteoporose
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Fosfatase Ácida
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Extratos Vegetais
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Prunus
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Frutas
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Isoenzimas
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Antioxidantes
Idioma:
En
Revista:
Food Chem
Ano de publicação:
2014
Tipo de documento:
Article