Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.
Biosci Trends
; 8(1): 32-7, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24647110
ABSTRACT
The present study is designed to search for the serum cytokine biomarker for liver injury induced by Dioscorea bulbifera L., which is a traditionally used herbal medicine in China. Mice were orally given various doses of ethyl acetate extract (EF) isolated from D. bulbifera for 12 days. The activity of serum alanine/aspartate transaminases (ALT/AST) was increased in EF (400 mg/kg)-treated mice. Histological assessment further confirmed EF (400 mg/kg)-induced liver injury. Results of a cytokine-antibody array demonstrated that there were 10 cytokines up-regulated and 1 cytokine down-regulated in EF (400 mg/kg)-treated mice. Enzyme-linked immunosorbent assay (ELISA) further confirmed the increased level of CD30 ligand (CD30L) and decreased level of interlukin-3 (IL-3) in EF-treated mice. In conclusion, our results demonstrate that the altered expression of CD30L and IL-3 may be potential biomarkers for hepatotoxicity induced by D. bulbifera.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Biomarcadores
/
Citocinas
/
Dioscorea
/
Doença Hepática Induzida por Substâncias e Drogas
Idioma:
En
Revista:
Biosci Trends
Ano de publicação:
2014
Tipo de documento:
Article