Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.
Phytomedicine
; 21(6): 877-82, 2014 May 15.
Article
em En
| MEDLINE
| ID: mdl-24680618
ABSTRACT
The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Assunto principal:
Compostos de Quinolínio
/
Extratos Vegetais
/
Carcinoma Hepatocelular
/
Rutaceae
/
Alcaloides
/
Fitoterapia
/
Antineoplásicos Fitogênicos
Idioma:
En
Revista:
Phytomedicine
Ano de publicação:
2014
Tipo de documento:
Article