A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease.
J Alzheimers Dis
; 41(3): 715-7, 2014.
Article
em En
| MEDLINE
| ID: mdl-24898653
ABSTRACT
Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2-3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naïve patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Suplementos Nutricionais
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Doença de Alzheimer
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Alzheimers Dis
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha