Effects of change in the formulation of lanthanum carbonate on laboratory parameters.
Ther Apher Dial
; 18 Suppl 1: 18-22, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24953762
ABSTRACT
Lanthanum carbonate (LC) is available in the two formulations of chewable tablets and granules. In this study, we changed the formulation of LC from chewable tablet to granules, and compared the laboratory parameters for 3 months before and after changing formulation in 58 hemodialysis (HD) patients. We also surveyed patients about their preferences for the two formulations. The mean serum phosphorus (P) levels decreased significantly (P < 0.01) from 6.7 mg/dL to 6.4 mg/dL after the change. The levels for serum albumin and geriatric nutritional risk index increased significantly (P < 0.01). Serum calcium levels also increased significantly (P < 0.01), while serum intact parathyroid hormone levels decreased significantly (P < 0.01). In the survey, approximately half of the patients responded that the granules were easier to take than the chewable tablets. These findings suggest that changing the formulation of LC to granules may reduce serum P levels of the HD patients in clinical practices.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fósforo
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Química Farmacêutica
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Diálise Renal
/
Lantânio
Tipo de estudo:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Ther Apher Dial
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Japão