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[Randomized controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum].
Mitomi, T; Tsuchiya, S; Iijima, N; Aso, K; Suzuki, K; Nishiyama, K; Amano, T; Takahashi, T; Murayama, N; Oka, H.
Afiliação
  • Mitomi T; Dept. of Surgery II, Tokai University.
Gan To Kagaku Ryoho ; 16(6): 2241-9, 1989 Jun.
Article em Ja | MEDLINE | ID: mdl-2500070
ABSTRACT
To evaluate of adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer, randomized controlled study by 35 institutions in Kanagawa prefecture was conducted. From March 1985 till February 1987, 462 patients were assigned one of two different regimens. 448 patients (97.0%) of them satisfied the eligibility criteria. Control group received mitomycin C intravenously on the day and the day after the operations respectively followed by 5-FU orally over for 6 months. PSK group received in addition to mitomycin C and 5-FU as in control group, PSK orally for over 3 years. By February 1989, follow up studies of the patients after their operations had been carried out for two years to four years. The disease free curve and the survival curve of PSK group were higher than those of control group, differences between the two groups were statistically significant (Disease free curve P = 0.0096, survival curve p = 0.0391). From these results, adjuvant immunochemotherapy with PSK was considered beneficial for curatively resected colorectal cancer.
Assuntos
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Base de dados: MEDLINE Assunto principal: Proteoglicanas / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Adjuvantes Imunológicos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: Ja Revista: Gan To Kagaku Ryoho Ano de publicação: 1989 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Proteoglicanas / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Adjuvantes Imunológicos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: Ja Revista: Gan To Kagaku Ryoho Ano de publicação: 1989 Tipo de documento: Article