Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-ß1/Smad signaling.

Shen, Nannan; Li, Xiaoguang; Zhou, Tong; Bilal, Muhammad U; Du, Ning; Hu, Yingying; Qin, Wei; Xie, Yingming; Wang, Hongtao; Wu, Jianwei; Ju, Jiaming; Fang, Zhiwei; Wang, Lihong; Zhang, Yong

Shen, Nannan; Li, Xiaoguang; Zhou, Tong; Bilal, Muhammad U; Du, Ning; Hu, Yingying; Qin, Wei; Xie, Yingming; Wang, Hongtao; Wu, Jianwei; Ju, Jiaming; Fang, Zhiwei; Wang, Lihong; Zhang, Yong.

Afiliação

Shen N; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Li X; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Zhou T; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Bilal MU; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Du N; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Hu Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Qin W; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Xie Y; Department of Endocrinology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Wang H; Hebei Yiling Pharmaceutical Research Institute, Shijiazhuang 050035, China.
Wu J; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Ju J; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Fang Z; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China.
Wang L; Department of Endocrinology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: nd6688@163.com.
Zhang Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China; Institute of Cardiovascular Research, Harbin Medical University, Harbin 150081, China

J Ethnopharmacol ; 157: 161-70, 2014 Nov 18.

Article em En | MEDLINE | ID: mdl-25267579

Assuntos

Diabetes Mellitus Experimental/tratamento farmacológico; Cardiomiopatias Diabéticas/tratamento farmacológico; Medicamentos de Ervas Chinesas/farmacologia; Fator de Crescimento Transformador beta1/metabolismo; Animais; Diabetes Mellitus Experimental/complicações; Cardiomiopatias Diabéticas/patologia; Regulação para Baixo/efeitos dos fármacos; Fibrose; Masculino; Miocárdio/patologia; Ratos; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos; Proteína Smad2/efeitos dos fármacos; Proteína Smad2/metabolismo; Proteína Smad3/efeitos dos fármacos; Proteína Smad3/metabolismo; Proteína Smad7/efeitos dos fármacos; Proteína Smad7/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Avicularin (Pubchem CID: 5490064); Berberine hydrochloride (Pubchem CID: 12456); Cardiac fibrosis; Columbamine (Pubchem CID: 72310); Demethyleneberberine (Pubchem CID: 363209); Diabetic cardiomyopathy; Ginsenoside Rb1 (Pubchem CID: 9898279 ); Linarin (Pubchem CID: 5317025); Nardosinone (Pubchem CID: 168136); Oleanic acid (Pubchem CID: 10494); Paeoniflorin (Pubchem CID: 442534); Quercetin (Pubchem CID: 5280343); Salvianolic acid B (Pubchem CID: 71433917 ); Salvianolic acid E (Pubchem CID: 49770697); Saponin (Pubchem CID: 11007422); Schisantherin A (Pubchem CID: 151529); Schizandrin B (Pubchem CID: 108130); Shensong Yangxin Capsule; Smad; Sodium danshensu (Pubchem CID: 23711819); Spinosin (Pubchem CID: 155692); TGF-ß1; Tanshinone I (Pubchem CID: 114917)

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Medicamentos de Ervas Chinesas / Diabetes Mellitus Experimental / Fator de Crescimento Transformador beta1 / Cardiomiopatias Diabéticas Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China

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