Markers of macromolecular oxidative damage in maternal serum and risk of neural tube defects in offspring.
Free Radic Biol Med
; 80: 27-32, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25542138
ABSTRACT
Neural tube defects (NTDs) are among the most common and severe congenital malformations. To examine the association between markers of macromolecular oxidative damage and risk of NTDs, we measured levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), protein carbonyl (PC), and 8-iso-prostaglandin F2α (8-iso-PGF2α) in maternal serum samples of 117 women with NTD-affected pregnancies and 121 women with healthy term newborns. We found higher levels of 8-OHdG and PC in the NTD group than in the control group; however, we did not observe a statistically significant difference in 8-iso-PGF2α levels between the NTD and the control groups. NTD risk increased with increasing quartiles of 8-OHdG [odds ratio (OR)=1.17; 95% confidence interval (CI) 0.39-3.51; OR=2.19; 95% CI, 0.68-7.01; OR=3.70; 95% CI, 1.30-10.51, for the second, third, and fourth quartile relative to the lowest quartile, respectively; P=0.009], and with increasing quartiles of PC (OR=2.26; 95% CI, 0.66-7.69; OR=3.86; 95% CI, 1.17-12.80; OR=5.98; 95% CI, 1.82-19.66, for the second, third, and fourth quartile relative to the lowest quartile, respectively; P=0.002]. Serum levels of 8-OHdG were higher in women who did not take folic acid supplements during the periconceptional period. These results suggest that oxidative stress is present in women carrying pregnancies affected by NTDs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
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Desoxiguanosina
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Ácido Fólico
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Defeitos do Tubo Neural
Tipo de estudo:
Etiology_studies
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Observational_studies
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Screening_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Free Radic Biol Med
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China