Effects of margarine enriched with plant sterol esters from rapeseed and tall oils on markers of endothelial function, inflammation and hemostasis.
Scand J Clin Lab Invest
; 75(2): 189-92, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25553599
ABSTRACT
BACKGROUND AND AIMS:
The sterol profile of rapeseed oil differs from that of tall oil with higher contents of campesterol and brassicasterol. We previously found that margarines providing 2 g/day of sterols from rapeseed or tall oil resulted in similar reductions in LDL cholesterol of 8-9%. The aim of the present study was to investigate whether the consumption of these margarines affected markers of endothelial function, inflammation and hemostasis.METHODS:
Blood samples were collected from 58 hypercholesterolemic volunteers who completed a double-blinded, randomized, crossover trial. Subjects consumed each of the two sterol margarines and a control non-sterol margarine for 4 weeks separated by one-week washout periods. All the margarines had the same fatty acid composition. Concentrations of vascular cell adhesion molecule-l (VCAM-1), E-selection, circulating tumor necrosis factor α (TNFα) and plasminogen activator inhibitor-1 (total, tPAI-1; active, PAI-1) were quantified.RESULTS:
Rapeseed-sterol margarine reduced E-selection concentrations compared to the control margarine (p = 0.012) while tall-sterol margarine had no effect. The rapeseed-sterol margarine also reduced tPAI-1 (p = 0.008) compared to the tall-sterol margarine. No significant changes were observed in TNFα and VCAM-1. No association was found between LDL reduction and changes in E-selection and tPAI-1.CONCLUSION:
Rapeseed-sterol margarine demonstrated favorable effects on vascular risk markers.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fitosteróis
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Endotélio Vascular
/
Hipercolesterolemia
/
Margarina
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Scand J Clin Lab Invest
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Noruega