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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Raheem, Izzat T; Breslin, Michael J; Bruno, Joseph; Cabalu, Tamara D; Cooke, Andrew; Cox, Christopher D; Cui, Donghui; Garson, Susan; Gotter, Anthony L; Fox, Steven V; Harrell, C Meacham; Kuduk, Scott D; Lemaire, Wei; Prueksaritanont, Thomayant; Renger, John J; Stump, Craig; Tannenbaum, Pamela L; Williams, Peter D; Winrow, Christopher J; Coleman, Paul J.
Afiliação
  • Raheem IT; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Breslin MJ; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Bruno J; In Vitro Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Cabalu TD; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, United States.
  • Cooke A; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Cox CD; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Cui D; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, United States.
  • Garson S; Neuroscience, Merck Research Laboratories, West Point, PA 19486, United States.
  • Gotter AL; Neuroscience, Merck Research Laboratories, West Point, PA 19486, United States.
  • Fox SV; In Vivo Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Harrell CM; Neuroscience, Merck Research Laboratories, West Point, PA 19486, United States.
  • Kuduk SD; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Lemaire W; In Vitro Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Prueksaritanont T; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, United States.
  • Renger JJ; Neuroscience, Merck Research Laboratories, West Point, PA 19486, United States.
  • Stump C; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Tannenbaum PL; In Vivo Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Williams PD; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Winrow CJ; Neuroscience, Merck Research Laboratories, West Point, PA 19486, United States.
  • Coleman PJ; Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
Bioorg Med Chem Lett ; 25(3): 444-50, 2015 Feb 01.
Article em En | MEDLINE | ID: mdl-25577040
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Pirimidinas / Éteres / Antagonistas dos Receptores de Orexina Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Pirimidinas / Éteres / Antagonistas dos Receptores de Orexina Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos