Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line.
Int J Food Sci Nutr
; 66(3): 293-9, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25582176
ABSTRACT
Many reports have shown promising beneficial effects of long-chain polyunsaturated fatty acids (L-PUFAs) of the omega 3 series in several brain diseases. In the present study, we tested the hypothesis that omega 3 fatty acids supplement reduced pro-inflammatory functions in vitro and in vivo. We demonstrated that a supplement rich in PUFAs (SRP) increased cell viability in a dose-dependent manner suggesting its protective role against lipopolysaccharide (LPS)-induced cell death in BV2 microglial cell line. In the same cultures, the supplement rich in PUFAs reduced the reactive oxygen species (ROS) and nitric oxide (NO) production. A most prominent target for ROS management is the family of peroxisome proliferator-activated receptors (PPARs). The co-treatment with SRP and LPS increased significantly the nuclear immunoreactivity of PPAR-γwhen compared the LPS treatment alone. Moreover, the chronic administration of the SRP in rats, increased the immunoreactivity of the PPAR-γ1 protein confirming its potential neuroprotective effect.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Espécies Reativas de Oxigênio
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Microglia
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Estresse Oxidativo
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Suplementos Nutricionais
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PPAR gama
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Inflamação
Idioma:
En
Revista:
Int J Food Sci Nutr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália