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Betamethasone augments the antifungal effect of menadione--towards a novel anti-Candida albicans combination therapy.
Jakab, Ágnes; Emri, Tamás; Sipos, Lilla; Kiss, Ágnes; Kovács, Renátó; Dombrádi, Viktor; Kemény-Beke, Ádám; Balla, József; Majoros, László; Pócsi, István.
Afiliação
  • Jakab Á; Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
  • Emri T; Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
  • Sipos L; Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
  • Kiss Á; Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
  • Kovács R; Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Dombrádi V; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Kemény-Beke Á; Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Balla J; Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Majoros L; Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Pócsi I; Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
J Basic Microbiol ; 55(8): 973-81, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25707543
ABSTRACT
The fluorinated glucocorticoid betamethasone stimulated both the extracellular phospholipase production and hypha formation of the opportunistic human pathogen Candida albicans and also decreased the efficiency of the polyene antimycotics amphotericin B and nystatin against C. albicans in a dose-dependent manner. Importantly, betamethasone increased synergistically the anti-Candida activity of the oxidative stress generating agent menadione, which may be exploited in future combination therapies to prevent or cure C. albicans infections, in the field of dermatology.
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Candida albicans / Candidíase / Betametasona / Vitamina K 3 / Antifúngicos Idioma: En Revista: J Basic Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Hungria
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Candida albicans / Candidíase / Betametasona / Vitamina K 3 / Antifúngicos Idioma: En Revista: J Basic Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Hungria