Cytotoxity of two new coumarin derivatives isolated from Launaea mucronata.
Nat Prod Res
; 30(4): 394-8, 2016.
Article
em En
| MEDLINE
| ID: mdl-25751124
ABSTRACT
The chloroform fraction of methanol (MeOH) extract of the aerial parts of Launaea mucronata was in vitro investigated for cytotoxicity against HCT116, HepG2 and MCF-7 cell lines, and resulted with IC50 = 20.0, 18.6 and 14.30 µg/mL, respectively. The chloroform fraction of the MeOH extract was subjected to further fractionation, which led to the isolation of two new coumarin compounds (6-isobutyl coumarin and 6-isobutyl-7-methyl- coumarin). The structures of the new compounds were elucidated by high field 1D and 2D NMR and ESI-MS spectroscopies. Low polar fractions revealed the isolation of other known triterpene compounds which were identified according to its spectral data and comparison with the literature. New coumarin compounds show high cytotoxicity against MCF-7, HCT116 and HepG2 cell lines.
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Base de dados:
MEDLINE
Assunto principal:
Asteraceae
/
Cumarínicos
/
Antineoplásicos Fitogênicos
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Egito