Molecular evolution of hypoallergenic hybrid proteins for vaccination against grass pollen allergy.

Linhart, Birgit; Focke-Tejkl, Margarete; Weber, Milena; Narayanan, Meena; Neubauer, Angela; Mayrhofer, Hannes; Blatt, Katharina; Lupinek, Christian; Valent, Peter; Valenta, Rudolf

Linhart, Birgit; Focke-Tejkl, Margarete; Weber, Milena; Narayanan, Meena; Neubauer, Angela; Mayrhofer, Hannes; Blatt, Katharina; Lupinek, Christian; Valent, Peter; Valenta, Rudolf.

Afiliação

Linhart B; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria;
Focke-Tejkl M; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, 1090 Vienna, Austria;
Weber M; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria;
Narayanan M; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria;
Neubauer A; Biomay AG, 1090 Vienna, Austria; and.
Mayrhofer H; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria;
Blatt K; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Lupinek C; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria;
Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Valenta R; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, 1090 Vienna, Austria; rudolf.

J Immunol ; 194(8): 4008-18, 2015 Apr 15.

Article em En | MEDLINE | ID: mdl-25786690

Assuntos

Alérgenos; Evolução Molecular Direcionada; Imunização; Phleum; Proteínas de Plantas; Pólen; Rinite Alérgica Sazonal/prevenção & controle; Alérgenos/genética; Alérgenos/imunologia; Alérgenos/farmacologia; Animais; Epitopos de Linfócito T/genética; Epitopos de Linfócito T/imunologia; Epitopos de Linfócito T/farmacologia; Feminino; Humanos; Imunoglobulina E/genética; Imunoglobulina E/imunologia; Imunoglobulina G/genética; Imunoglobulina G/imunologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Phleum/genética; Phleum/imunologia; Proteínas de Plantas/genética; Proteínas de Plantas/imunologia; Proteínas de Plantas/farmacologia; Pólen/genética; Pólen/imunologia; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/imunologia; Proteínas Recombinantes de Fusão/farmacologia; Rinite Alérgica Sazonal/genética; Rinite Alérgica Sazonal/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Plantas / Pólen / Alérgenos / Rinite Alérgica Sazonal / Imunização / Evolução Molecular Direcionada / Phleum Idioma: En Revista: J Immunol Ano de publicação: 2015 Tipo de documento: Article

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