Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.
Hum Exp Toxicol
; 35(2): 205-12, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-25805601
ABSTRACT
Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.
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Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
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Ciclofosfamida
/
Alquilantes
Idioma:
En
Revista:
Hum Exp Toxicol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Índia