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Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells.
Wang, Chia-Woei; Wang, Chien-Kai; Chang, Yu-Jia; Choong, Chen-Yen; Lin, Chi-Shian; Tai, Cheng-Jeng; Tai, Chen-Jei.
Afiliação
  • Wang CW; Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 110, Taiwan ; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Wang CK; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei 110, Taiwan ; Department of Internal
  • Chang YJ; Cancer Research Center, Taipei Medical University and Hospital, Taipei 110, Taiwan ; Department of Surgery, Taipei Medical University and Hospital, Taipei 110, Taiwan ; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiw
  • Choong CY; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Lin CS; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Tai CJ; Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei 110, Taiwan ; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Tai CJ; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Chinese Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei 110, Taiwan ; Traditional Herbal Medicine Research Center, Taipei Medical
Article em En | MEDLINE | ID: mdl-25815037
Fermented wheat germ extract (FWGE) is a nutrient supplement and a potential antitumor ingredient for developing an integrated chemotherapy with standard chemotherapeutic drugs for treating ovarian cancer patients. In this study, we evaluated the tumor suppression efficiency of FWGE in human ovarian carcinoma cells, SKOV-3 and ES-2, and found the half-maximal inhibitory concentrations (IC50s) to be 643.76 µg/mL and 246.11 µg/mL after 48 h of FWGE treatment. FWGE treatment also induced programmed cell death by activating the caspase-7 cleavage in both SKOV-3 and ES-2 cells, but only caspase-3 and poly(adenosine diphosphate-ribose) polymerase cleavages were activated in SKOV-3 cells. Moreover, FWGE exhibited combination drug effects with cisplatin and docetaxel in SKOV-3 and ES-2 cells by enhancing the cytotoxicity of both drugs. In conclusion, we found that FWGE not only suppressed cell growth but also induced caspase-3-related and caspase-7-related cell death in human ovarian carcinoma cells. FWGE treatment further enhanced the cytotoxicity of cisplatin and docetaxel, suggesting that FWGE is a potential ingredient in the development of adjuvant chemotherapy with cisplatin or docetaxel for treating ovarian cancer patients.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan