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Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats.
Fan, Xing-Wen; Chen, Fu; Chen, Yan; Chen, Guan-Hao; Liu, Huan-Huan; Guan, Shi-Kuo; Deng, Yun; Liu, Yong; Zhang, Sheng-Jian; Peng, Wei-Jun; Jiang, Guo-Liang; Wu, Kai-Liang.
Afiliação
  • Fan XW; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
  • Chen F; Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
  • Chen Y; Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
  • Chen GH; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
  • Liu HH; Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China, 200032.
  • Guan SK; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
  • Deng Y; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
  • Liu Y; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
  • Zhang SJ; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
  • Peng WJ; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
  • Jiang GL; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
  • Wu KL; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
PLoS One ; 10(4): e0122087, 2015.
Article em En | MEDLINE | ID: mdl-25830357
ABSTRACT
Cognitive impairments severely affect the quality of life of patients who undergo brain irradiation, and there are no effective preventive strategies. In this study, we examined the therapeutic potential of electroacupuncture (EA) administered immediately after brain irradiation in rats. We detected changes in cognitive function, neurogenesis, and synaptic density at different time points after irradiation, but found that EA could protect the blood-brain barrier (BBB), inhibit neuroinflammatory cytokine expression, upregulate angiogenic cytokine expression, and modulate the levels of neurotransmitter receptors and neuropeptides in the early phase. Moreover, EA protected spatial memory and recognition in the delayed phase. At the cellular/molecular level, the preventative effect of EA on cognitive dysfunction was not dependent on hippocampal neurogenesis; rather, it was related to synaptophysin expression. Our results suggest that EA applied immediately after brain irradiation can prevent cognitive impairments by protecting against the early changes induced by irradiation and may be a novel approach for preventing or ameliorating cognitive impairments in patients with brain tumors who require radiotherapy.
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_energeticas Assunto principal: Lesões Experimentais por Radiação / Eletroacupuntura / Transtornos Cognitivos Idioma: En Revista: PLoS One Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_energeticas Assunto principal: Lesões Experimentais por Radiação / Eletroacupuntura / Transtornos Cognitivos Idioma: En Revista: PLoS One Ano de publicação: 2015 Tipo de documento: Article