Simultaneous LC-MS/MS determination of five tripterygium pyridine alkaloids in dog plasma and its application to their pharmacokinetic study after oral administration of tripterygium glycosides tablets.

Su, Meng-xiang; Song, Min; Yang, Da-song; Shi, Jin-fang; Di, Bin; Hang, Tai-jun

Su, Meng-xiang; Song, Min; Yang, Da-song; Shi, Jin-fang; Di, Bin; Hang, Tai-jun.

Afiliação

Su MX; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China.
Song M; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China.
Yang DS; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China.
Shi JF; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China.
Di B; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China.
Hang TJ; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China. Electronic address: hangtj@cpu.edu.cn.

J Chromatogr B Analyt Technol Biomed Life Sci ; 990: 31-8, 2015 May 15.

Article em En | MEDLINE | ID: mdl-25855315

Assuntos

Alcaloides/sangue; Cromatografia Líquida/métodos; Piridinas/sangue; Comprimidos/química; Espectrometria de Massas em Tandem/métodos; Tripterygium/química; Administração Oral; Alcaloides/química; Alcaloides/farmacocinética; Animais; Cães; Estabilidade de Medicamentos; Medicamentos de Ervas Chinesas; Modelos Lineares; Piridinas/química; Piridinas/farmacocinética; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Comprimidos/administração & dosagem

Palavras-chave

LCMS/MS; Triptolide; Wilfording; Wilforgine; Wilforine; Wilfortrine

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Piridinas / Comprimidos / Cromatografia Líquida / Tripterygium / Alcaloides / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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