Paradigm Shifts in Atherosclerotic Renovascular Disease: Where Are We Now?
J Am Soc Nephrol
; 26(9): 2074-80, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25868641
ABSTRACT
Results of recent clinical trials and experimental studies indicate that whereas atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue injury in the poststenotic kidney, restoring vessel patency alone is insufficient to recover kidney function for most subjects. Kidney injury in atherosclerotic renovascular disease reflects complex interactions among vascular rarefication, oxidative stress injury, and recruitment of inflammatory cellular elements that ultimately produce fibrosis. Classic paradigms for simply restoring blood flow are shifting to implementation of therapy targeting mitochondria and cell-based functions to allow regeneration of vascular, glomerular, and tubular structures sufficient to recover, or at least stabilize, renal function. These developments offer exciting possibilities of repair and regeneration of kidney tissue that may limit progressive CKD in atherosclerotic renovascular disease and may apply to other conditions in which inflammatory injury is a major common pathway.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Obstrução da Artéria Renal
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Insuficiência Renal Crônica
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Aterosclerose
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Rim
/
Nefrite
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
J Am Soc Nephrol
Ano de publicação:
2015
Tipo de documento:
Article