Anti-tumor activities of active ingredients in Compound Kushen Injection.
Acta Pharmacol Sin
; 36(6): 676-9, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25982630
ABSTRACT
Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Medicamentos de Ervas Chinesas
/
Medicina Tradicional Chinesa
/
Neoplasias
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Acta Pharmacol Sin
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China