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Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells.
Miura, Yoko; Oyama, Masayoshi; Iguchi, Kazuhiro; Ito, Tetsuro; Baba, Misako; Shikama, Yuji; Usui, Shigeyuki; Hirano, Kazuyuki; Iinuma, Munekazu; Mikamo, Hiroshige.
Afiliação
  • Miura Y; Department of Infection Control and Prevention, Aichi Medical University.
J Nutr Sci Vitaminol (Tokyo) ; 61(2): 201-4, 2015.
Article em En | MEDLINE | ID: mdl-26052153
ABSTRACT
Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Próstata / Neoplasias da Próstata / Flavonoides / Epimedium / Antagonistas de Androgênios / Androgênios / Fitoterapia Idioma: En Revista: J Nutr Sci Vitaminol (Tokyo) Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Próstata / Neoplasias da Próstata / Flavonoides / Epimedium / Antagonistas de Androgênios / Androgênios / Fitoterapia Idioma: En Revista: J Nutr Sci Vitaminol (Tokyo) Ano de publicação: 2015 Tipo de documento: Article