Calcitonin suppresses intervertebral disk degeneration and preserves lumbar vertebral bone mineral density and bone strength in ovariectomized rats.

Tian, F-m; Yang, K; Wang, W-y; Luo, Y; Li, S-y; Song, H-p; Zhang, Y-z; Shen, Y; Zhang, L

Tian, F-m; Yang, K; Wang, W-y; Luo, Y; Li, S-y; Song, H-p; Zhang, Y-z; Shen, Y; Zhang, L.

Afiliação

Tian FM; Medical Research Center, Affiliated Hospital of Hebei United University, Tangshan, People's Republic of China.
Yang K; Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, No. 73 Jianshe South Rd, Tangshan, 063000, Hebei, People's Republic of China.
Wang WY; Department of Pathology of Basic Medical Sciences School, Hebei United University, Tangshan, People's Republic of China.
Luo Y; Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Li SY; Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, No. 73 Jianshe South Rd, Tangshan, 063000, Hebei, People's Republic of China.
Song HP; Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, No. 73 Jianshe South Rd, Tangshan, 063000, Hebei, People's Republic of China.
Zhang YZ; Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Shen Y; Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Zhang L; Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, No. 73 Jianshe South Rd, Tangshan, 063000, Hebei, People's Republic of China. zhliu130@sohu.com.

Osteoporos Int ; 26(12): 2853-61, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26104796

Assuntos

Conservadores da Densidade Óssea/uso terapêutico; Densidade Óssea/efeitos dos fármacos; Doenças Ósseas Metabólicas/prevenção & controle; Calcitonina/uso terapêutico; Degeneração do Disco Intervertebral/prevenção & controle; Vértebras Lombares/fisiopatologia; Animais; Doenças Ósseas Metabólicas/patologia; Doenças Ósseas Metabólicas/fisiopatologia; Colágeno Tipo II/metabolismo; Avaliação Pré-Clínica de Medicamentos/métodos; Feminino; Degeneração do Disco Intervertebral/diagnóstico por imagem; Degeneração do Disco Intervertebral/patologia; Degeneração do Disco Intervertebral/fisiopatologia; Vértebras Lombares/diagnóstico por imagem; Vértebras Lombares/patologia; Metaloproteinase 1 da Matriz/metabolismo; Metaloproteinase 13 da Matriz/metabolismo; Ovariectomia; Estresse Mecânico; Microtomografia por Raio-X/métodos

Palavras-chave

Biomechanics; Intervertebral disk degeneration; Micro-computed tomography; Osteopenia; Salmon calcitonin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Ósseas Metabólicas / Calcitonina / Densidade Óssea / Conservadores da Densidade Óssea / Degeneração do Disco Intervertebral / Vértebras Lombares Idioma: En Revista: Osteoporos Int Ano de publicação: 2015 Tipo de documento: Article

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