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New strategies for local treatment of vaginal infections.
Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José.
Afiliação
  • Palmeira-de-Oliveira R; CICS-UBI: Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal; Pharmacy Department, Centro Hospitalar Cova da Beira, Quinta do Alvito, 6200-251 Covilhã, Portugal; Labfit-Health Products Research and Development (HPRD), Lda, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal. Electronic address: rpo@fcsaude.ubi.pt.
  • Palmeira-de-Oliveira A; CICS-UBI: Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal; Pharmacy Department, Centro Hospitalar Cova da Beira, Quinta do Alvito, 6200-251 Covilhã, Portugal.
  • Martinez-de-Oliveira J; CICS-UBI: Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal; Child and Woman's Health Department, Centro Hospitalar Cova da Beira Quinta do Alvito, 6200-251 Covilhã, Portugal.
Adv Drug Deliv Rev ; 92: 105-22, 2015 Sep 15.
Article em En | MEDLINE | ID: mdl-26144995
Vaginal infections are extremely prevalent, particularly among women of reproductive age. Although they do not result in high mortality rates, these infections are associated with high levels of anxiety and reduction of quality of life. In most cases, topical treatment of vaginal infections has been shown to be at least as effective as oral treatment, resulting in higher local drug concentrations, with fewer drug interactions and adverse effects. Furthermore, the emergence of microbial resistance to chemotherapeutics and the difficulties in managing infection recurrences sustain the need for more effective local treatments. However, conventional dosage forms have been associated with low retention in the vagina and discomfort. Formulation strategies such as the development of bioadhesive, thermogelling systems and microtechnological or nanotechnological approaches have been proposed to improve delivery of traditional drugs, and other treatment modalities such as new drugs, plant extracts, and probiotics are being studied. This article reviews the recent strategies studied to improve the treatment and prevention of the commonest vaginal infections-namely, vaginal bacteriosis, aerobic vaginitis, vulvovaginal candidosis, and trichomoniasis-through the intravaginal route.
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Aromoterapia Assunto principal: Cremes, Espumas e Géis Vaginais / Vaginite / Tecnologia Farmacêutica / Sistemas de Liberação de Medicamentos / Antibacterianos Idioma: En Revista: Adv Drug Deliv Rev Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Aromoterapia Assunto principal: Cremes, Espumas e Géis Vaginais / Vaginite / Tecnologia Farmacêutica / Sistemas de Liberação de Medicamentos / Antibacterianos Idioma: En Revista: Adv Drug Deliv Rev Ano de publicação: 2015 Tipo de documento: Article