[Pathomorphology of the reparative processes of the liver following praziquantel treatment of experimental opisthorchiasis]. / Patomorfologiia vosstanovitel'nykh protsessov v pecheni posle lecheniia éksperimental'nogo opistorkhoza prazikvantelem.

ABSTRACT

The authors attempted to create a model of reparative processes in the liver in the residual period of experimental opisthorchiasis. The experiment was performed in 150 Opisthorchis invaded Syrian hamsters treated with praziquantel in a single dose of 400 mg/kg body weight on days 7-180 of postinfection. The studies of morphological, histochemical and morphometric alterations in the animal liver allowed one to distinguish the stages of additional sensitization, early and late rehabilitative changes and the stage of residual changes. An inverse relationship was found between the duration of last three stages with the invasion duration prior to treatment and with increased duration of the first stage of the disease in early therapy.