Multifunctional magnetic-hollow gold nanospheres for bimodal cancer cell imaging and photothermal therapy.
Nanotechnology
; 26(31): 315701, 2015 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-26177713
ABSTRACT
Multifunctional nanocomposites combining imaging and therapeutic functions have great potential for cancer diagnosis and therapy. In this work, we developed a novel theranostic agent based on hollow gold nanospheres (HGNs) and superparamagnetic iron oxide nanoparticles (SPIO). Taking advantage of the excellent magnetic properties of SPIO and strong near-infrared (NIR) absorption property of HGNs, such nanocomposites were applied to targeted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) of cancer cells. In vitro results demonstrated they displayed significant contrast enhancement for T2-weighted MRI and strong PAI signal enhancement. Simultaneously, the nanocomposites exhibited a high photothermal effect under the irradiation of the near-infrared laser and can be used as efficient photothermal therapy (PTT) agents for selective killing of cancer cells. All these results indicated that such nanocomposites combined with MRI-PAI and PTT functionality can have great potential for effective cancer diagnosis and therapy.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_energeticas
/
Magnetoterapia
Assunto principal:
Imageamento por Ressonância Magnética
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Meios de Contraste
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Terapia com Luz de Baixa Intensidade
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Nanosferas
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Técnicas Fotoacústicas
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Neoplasias
Idioma:
En
Revista:
Nanotechnology
Ano de publicação:
2015
Tipo de documento:
Article