Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase.
Fitoterapia
; 108: 20-5, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26586619
ABSTRACT
A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L. mesenteroides G6PD.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
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Rodófitas
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Glucosefosfato Desidrogenase
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão