Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
Fitoterapia
; 108: 55-61, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26598138
ABSTRACT
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Raízes de Plantas
/
Antialérgicos
/
Paeonia
/
Monoterpenos
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão