Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss.
Hear Res
; 332: 55-60, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26639015
ABSTRACT
Systemic and local changes in body temperature can have a profound effect on traumatic injuries including those to the inner ear. Therefore, we investigated the effects of acutely increasing or decreasing the temperature of the external ear canal on cisplatin-induced hearing loss. The external auditory canals of male guinea pigs were acutely irrigated with warm (44 °C), euthermic (37 °C), or cool (30 °C) water and subsequently injected with cisplatin (12 mg/kg, i.p.). Hearing was assessed by the auditory brainstem response and cochleograms were prepared to determine loss of hair cells. Ear canal irrigation with warm water potentiated cisplatin-induced hearing loss and outer hair cell loss whereas cool ear canal irrigation showed significant protection from cisplatin-induced hearing loss and outer hair cell loss. These results suggest that non-invasive cool water ear canal irrigation may be highly effective clinical procedure for protecting against cisplatin-induced hearing loss.
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Base de dados:
MEDLINE
Assunto principal:
Regulação da Temperatura Corporal
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Cisplatino
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Meato Acústico Externo
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Perda Auditiva
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Hipotermia Induzida
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Irrigação Terapêutica
Idioma:
En
Revista:
Hear Res
Ano de publicação:
2016
Tipo de documento:
Article