Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People.
J Alzheimers Dis
; 50(1): 149-59, 2016.
Article
em En
| MEDLINE
| ID: mdl-26682691
ABSTRACT
Our goal in this study was to determine whether or not anserine/carnosine supplementation (ACS) is capable of preserving cognitive function of elderly people. In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 11 ratio. The ACS group took 1.0âg of an anserine/carnosine (31) formula daily for 3 months. Participants were evaluated by psychological tests before and after the 3-month supplementation period. Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests. Among the tests, delayed recall verbal memory assessed by the Wechsler Memory Scale-Logical Memory showed significant preservation in the ACS group, compared to the placebo group (pâ=â0.0128). Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group. MRI analysis using arterial spin labeling showed a suppression in the age-related decline in brain blood flow in the posterior cingulate cortex area in the ACS group, compared to the placebo group (pâ=â0.0248). In another randomized controlled trial, delayed recall verbal memory showed significant preservation in the ACS group, compared to the placebo group (pâ=â0.0202). These results collectively suggest that ACS may preserve verbal episodic memory and brain perfusion in elderly people, although further study is needed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem Verbal
/
Envelhecimento
/
Carnosina
/
Memória Episódica
/
Anserina
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
J Alzheimers Dis
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão