Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.
J Neurol Neurosurg Psychiatry
; 87(6): 580-8, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26733601
ABSTRACT
OBJECTIVE:
To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS).METHODS:
T1-weighted, diffusion weighted and resting state functional MRI data were acquired at 3â T for 12 asymptomatic mutation carriers (psALS), 12 age-matched controls and affected patients with ALS. Cortical thickness analysis, voxel-based morphometry, volumetric and shape analyses of subcortical structures, tract-based spatial statistics of metrics derived from the diffusion tensor, and resting state functional connectivity (FC) analyses were performed.RESULTS:
Grey matter cortical thickness and shape analysis revealed significant atrophy in patients with ALS (but not psALS) compared with controls in the right primary motor cortex and right caudate. Comparison of diffusion tensor metrics showed widespread fractional anisotropy and radial diffusivity differences in patients with ALS compared to controls and the psALS group, encompassing parts of the corpus callosum, corticospinal tracts and superior longitudinal fasciculus. While FC in the resting-state sensorimotor network was similar in psALS and controls, FC between the cerebellum and a network comprising the precuneus, cingulate & middle frontal lobe was significantly higher in psALS and affected ALS compared to controls.CONCLUSIONS:
Rather than structural brain changes, increased FC may be among the earliest detectable brain abnormalities in asymptomatic carriers of ALS-causing gene mutations. With replication and significant refinement, this technique has potential in the future assessment of neuroprotective strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Interpretação de Imagem Assistida por Computador
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Predisposição Genética para Doença
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Imagem de Difusão por Ressonância Magnética
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Esclerose Lateral Amiotrófica
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Rede Nervosa
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido