Venous Invasion in Colorectal Cancer: Impact of Morphologic Findings on Detection Rate.
Cancer Res Treat
; 48(4): 1222-1228, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-26875194
ABSTRACT
PURPOSE:
Venous invasion (VI) is widely accepted as a poor prognostic factor in colorectal cancer (CRC), and is indicated as a high-risk factor determining the use of adjuvant chemotherapy in CRC. However, there is marked interobserver and intraobserver variability in VI identification and marked variability in the real prevalence of VI in CRC. MATERIALS ANDMETHODS:
We investigated the detection rate of VI in 93 consecutive cases of T3 or T4 CRC based on the following original pathology report, review of hematoxylin and eosin (H&E) slides with attention to the "protruding tongue" and "orphan arteriole" signs, and elastic stain as the gold standard.RESULTS:
Overall, the detection rate of VI was significantly increased as follows 14/93 (15.1%) in the original pathology report, 38/93 (40.9%) in review of H&E slides with attention to the "protruding tongue" and "orphan arteriole" signs, and 45/93 (48.4%) using elastic stain. VI detection based on morphologic features showed 77.8% sensitivity and 91.1% specificity and showed a linear correlation (Spearman correlation coefficient, 0.727; p < 0.001) with VI detected by elastic stain. In addition, improved agreement between detection methods (detection on the basis of morphologic features, κ=0.719 vs. original pathology report, κ=0.318) was observed using kappa statistics.CONCLUSION:
Slide review with special attention to the "protruding tongue" and "orphan arteriole" signs could be used for better identification of VI in CRC in routine surgical practice.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Veias
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Neoplasias Colorretais
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Neoplasias Vasculares
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Invasividade Neoplásica
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Cancer Res Treat
Ano de publicação:
2016
Tipo de documento:
Article