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Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial.
Huijbers, Marloes J; Spinhoven, Philip; Spijker, Jan; Ruhé, Henricus G; van Schaik, Digna J F; van Oppen, Patricia; Nolen, Willem A; Ormel, Johan; Kuyken, Willem; van der Wilt, Gert Jan; Blom, Marc B J; Schene, Aart H; Rogier, A; Donders, T; Speckens, Anne E M.
Afiliação
  • Huijbers MJ; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Spinhoven P; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Spijker J; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Ruhé HG; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • van Schaik DJ; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • van Oppen P; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Nolen WA; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Ormel J; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Kuyken W; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • van der Wilt GJ; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Blom MB; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Schene AH; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Rogier A; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Donders T; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
  • Speckens AE; Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, P
Br J Psychiatry ; 208(4): 366-73, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26892847
BACKGROUND: Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied. AIMS: To investigate whether MBCT with discontinuation of mADM is non-inferior to MBCT+mADM. METHOD: A multicentre randomised controlled non-inferiority trial (ClinicalTrials.gov:NCT00928980). Adults with recurrent depression in remission, using mADM for 6 months or longer (n= 249), were randomly allocated to either discontinue (n= 128) or continue (n= 121) mADM after MBCT. The primary outcome was depressive relapse/recurrence within 15 months. A confidence interval approach with a margin of 25% was used to test non-inferiority. Key secondary outcomes were time to relapse/recurrence and depression severity. RESULTS: The difference in relapse/recurrence rates exceeded the non-inferiority margin and time to relapse/recurrence was significantly shorter after discontinuation of mADM. There were only minor differences in depression severity. CONCLUSIONS: Our findings suggest an increased risk of relapse/recurrence in patients withdrawing from mADM after MBCT.
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_mente_y_cuerpo / Meditacion Assunto principal: Terapia Cognitivo-Comportamental / Transtorno Depressivo Maior / Atenção Plena / Antidepressivos Tipo de estudo: Clinical_trials Idioma: En Revista: Br J Psychiatry Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_mente_y_cuerpo / Meditacion Assunto principal: Terapia Cognitivo-Comportamental / Transtorno Depressivo Maior / Atenção Plena / Antidepressivos Tipo de estudo: Clinical_trials Idioma: En Revista: Br J Psychiatry Ano de publicação: 2016 Tipo de documento: Article