[Leptin Signalings and Leptin Resistance].
Sheng Li Ke Xue Jin Zhan
; 46(5): 327-33, 2015 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-26904854
ABSTRACT
Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin function is closely involved in the pathogenesis of obesity, diabetes mellitus and some other metabolic diseases. Leptin initiates intracellular signal transductions in the leptin-receptor-expressing neurons in the central nervous system to exert its physiological functions. The fact that high circulating levels of leptin partially or completely fail to promote weight loss in obesity has given rise to the notion of "leptin resistance". Recently, the impairment of leptin signalings in the hypothalamus has been regarded as a critical contributor to leptin resistance. In this review, the studies on leptin signaling and leptin resistance are summarized with an emphasis on the progress made during the last five years.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
Idioma:
Zh
Revista:
Sheng Li Ke Xue Jin Zhan
Ano de publicação:
2015
Tipo de documento:
Article