Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging.
ACS Nano
; 10(4): 4184-91, 2016 04 26.
Article
em En
| MEDLINE
| ID: mdl-26959856
ABSTRACT
Despite all the advances in multimodal imaging, it remains a significant challenge to acquire both magnetic resonance and nuclear imaging in a single dose because of the enormous difference in sensitivity. Indeed, nuclear imaging is almost 10(6)-fold more sensitive than magnetic resonance imaging (MRI); thus, repeated injections are generally required to obtain sufficient MR signals after nuclear imaging. Here, we show that strategically engineered magnetoferritin nanoprobes can image tumors with high sensitivity and specificity using SPECT and MRI in living mice after a single intravenous injection. The magnetoferritin nanoprobes composed of (125)I radionuclide-conjugated human H-ferritin iron nanocages ((125)I-M-HFn) internalize robustly into cancer cells via a novel tumor-specific HFn-TfR1 pathway. In particular, the endocytic recycling characteristic of TfR1 transporters solves the nuclear signal blocking issue caused by the high dose nanoprobes injected for MRI, thus enabling simultaneous functional and morphological tumor imaging without reliance on multi-injections.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Óxidos
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Apoferritinas
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Meios de Contraste
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Compostos Radiofarmacêuticos
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Nanopartículas de Magnetita
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Ferro
Idioma:
En
Revista:
ACS Nano
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China