Shed Pleural Blood from Traumatic Hemothorax Contains Elevated Levels of Pro-Inflammatory Cytokines.
Shock
; 46(2): 144-8, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-26974427
ABSTRACT
PURPOSE:
The autotransfusion of unwashed (or unprocessed) shed hemothorax blood (USHB) in trauma patients is widely assumed to be beneficial; however, the inflammatory potential of shed pleural blood has not been thoroughly studied. Since previous studies have documented marked changes in coagulation function of shed pleural blood, we hypothesized that its level of inflammatory cytokines would be elevated.METHODS:
A prospective observational study of trauma patients in whom cytokine levels from USHB were compared to venous samples from healthy volunteers was conducted. Differences between the cytokine content of patient-derived samples were compared to those from healthy subjects.RESULTS:
There was a statistically significant increase in pro-inflammatory cytokines (IL-6, IL-8, TNFα, GM-CSF), a pro-inflammatory Th-1 cytokine (IFNγ), and anti-inflammatory Th-2 cytokines (IL-4 and IL-10) in shed pleural blood over four hours when compared with samples from healthy controls (Pâ<0.05). Cytokine levels in USHB are approximately 10- to 100-fold higher compared with healthy control venous samples.CONCLUSIONS:
USHB, even collected within the accepted four-hour window, contains significantly elevated cytokine levels, suggesting the potential for deleterious effects from autotransfusion. Randomized trials are needed to determine the safety and efficacy of autotransfusion in trauma patients.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Hemoterapia
Assunto principal:
Traumatismos Torácicos
/
Ferimentos e Lesões
/
Citocinas
/
Hemotórax
Tipo de estudo:
Clinical_trials
/
Observational_studies
Idioma:
En
Revista:
Shock
Ano de publicação:
2016
Tipo de documento:
Article