PUFAs, Bone Mineral Density, and Fragility Fracture: Findings from Human Studies.
Adv Nutr
; 7(2): 299-312, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26980813
ABSTRACT
Osteoporosis is a global health problem that leads to an increased incidence of fragility fracture. Recent dietary patterns of Western populations include higher than recommended intakes of n-6 (ω-6) polyunsaturated fatty acids (PUFAs) relative to n-3 (ω-3) PUFAs that may result in a chronic state of sterile whole body inflammation. Findings from human bone cell culture experiments have revealed both benefits and detriments to bone-related outcomes depending on the quantity and source of PUFAs. Findings from observational and randomized controlled trials suggest that higher fatty fish intake is strongly linked with reduced risk of fragility fracture. Moreover, human studies largely support a greater intake of total PUFAs, total n-6 (ω-6) fatty acid, and total n-3 (ω-3) fatty acid for higher bone mineral density and reduced risk of fragility fracture. Less consistent evidence has been observed when investigating the role of long chain n-3 (ω-3) PUFAs or the ratio of n-6 (ω-6) PUFAs to n-3 (ω-3) PUFAs. Aspects to consider when interpreting the current literature involve participant characteristics, study duration, diet assessment tools, and the primary outcome measure.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Osteoporose Pós-Menopausa
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Saúde Global
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Alimentos Marinhos
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Medicina Baseada em Evidências
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Fraturas por Osteoporose
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Peixes
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
Idioma:
En
Revista:
Adv Nutr
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Canadá