The effect of butylphthalide on aminoacid content in the brain of epileptic mice.

ABSTRACT

BACKGROUND: The aim of this study is to observe the effect of butylphthalide (NBP) on the amino acid content in the brain of epileptic mice. METHODS: NBP was injected intraperitoneally into the mice, and acute epileptic mice models were made after 30 minutes. The change of the four amino (aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in the brain of the epileptic mice was investigated. RESULTS: The contents of Glu and Glu/GABA (control group 38.78, NBP high-dose group 5.52) in the NBP high-dose group were lower compared with the control group. The difference was statistically significant. CONCLUSIONS: NBP could regulate the balance of excitement and inhibition systems by reducing the contents of Glu and Glu/GABA, which might relieve seizures.